Publications – National Metabolomics Platform

Publications

2023(Jan - Aug)

1.Tuberculosis is associated with sputum metabolome variations, irrespective of patient sex or HIV status: an untargeted GCxGC-TOFMS study. Metabolomics, 19(6), p.55.
Beukes, D., van Reenen, M., Loots, D.T. and du Preez, I., 2023.

2.1H-NMR protocol for rapid diagnosis of purine and pyrimidine metabolic disorders in urine. STAR protocols, 4(2), p.102181.
Davoren, E. and Mason, S., 2023.

3.Evaluation of BAYESIL for automated annotation of 1H NMR data using limited sample volumes: application to African elephant serum. Metabolomics, 19(4), p.31.
van Zyl, C.D.W., van Reenen, M., Osthoff, G. and du Preez, I., 2023.

4.The glycine N-acyltransferases, GLYAT and GLYATL1, contribute to the detoxification of isovaleryl-CoA-an in-silico and in vitro validation. Computational and Structural Biotechnology Journal, 21, pp.1236-1248.
Kühn, S., Williams, M.E., Dercksen, M., Sass, J.O. and van der Sluis, R., 2023.

5.Reviews in metabolomics: Personalized and predictive medicine of infectious diseases. Frontiers in Molecular Biosciences, 10, p.1178115.
Du Preez, I. and Long, N.P., 2023.

6.Miniaturization and Automation Protocol of a Urinary Organic Acid Liquid-Liquid Extraction Method on GC-MS. Molecules, 28(15), p.5927.
Phiri, M.M., Davoren, E. and Vorster, B.C., 2023.

7.Introducing the South African Rare Diseases Access Initiative. South African Medical Journal, pp.8-8.
Malherbe, H., 2023.

8.A review of key terminology and definitions used for birth defects globally. Journal of community genetics, pp.1-22.
Malherbe, H.L., Modell, B., Blencowe, H., Strong, K.L. and Aldous, C., 2023.

9.It's a Small World After All… or Is It?. Biopreservation and Biobanking, 21(2), pp.219-220.
Allocca, C.M., Conradie, E., Furuta, K., McGarvey, D. and Parry-Jones, A., 2023.

10.Non-Enzymatic Formation of N-acetylated Amino Acid Conjugates in Urine. Applied Sciences, 13(18), p.10002.
Jacobs, J., van Sittert, C.G.C.E., Mienie, L.J., Dercksen, M., Opperman, M. and Vorster, B.C., 2023.

11.Feasibility ofNAD(P)/NAD(P)H as redox agents in enzymaticplasmonic gold nanostar assays for galactosequantification.
Munyayi TA, Mulder DW,Conradie EH, Vorster BC. 2023.

12.Metabolomic Profiling of Hormonal Contraceptive Use in Young Females Using a Commercially Available LC-MS/MS Kit. Metabolites, 13(10), p.1092.
Grobler, T., Opperman, M., Bester, J., Swanepoel, A.C. and du Preez, I., 2023.

13.Quantitative Galactose Colorimetric Competitive Assay Based on Galactose Dehydrogenase and Plasmonic Gold Nanostars. Biosensors, 13(11), p.965.
Munyayi, T.A., Mulder, D.W., Conradie, E.H., Smit F., J. and Vorster, B.C., 2023.

14.Safety Properties of Escherichia coli O157: H7 Specific Bacteriophages: Recent Advances for Food Safety. Foods, 12(21), p.3989.
Oluwarinde, B.O., Ajose, D.J., Abolarinwa, T.O., Montso, P.K., Du Preez, I., Njom, H.A. and Ateba, C.N., 2023.

15.The advantages of rare disease biobanking: A localised source of genetic knowledge to benefit the South African rare disease community and related stakeholders worldwide. South African Medical Journal, pp.9-9.
Dercksen, M., Conradie, E.H., Hendriksz, C.J., Malherbe, H. and Vorster, B.C., 2023.

1.FACTORS CONTRIBUTING TO PULMONARY TB TREATMENT LOST TO FOLLOW-UP IN DEVELOPING COUNTRIES: AN OVERVIEW. African Journal of Infectious Diseases (AJID), 17(1), pp.60-73.
OPPERMAN, M. and DU PREEZ, I., 2023.

2.M. tuberculosis curli pili (MTP) facilitates a reduction of microbicidal activity of infected THP-1 macrophages during early stages of infection. Comparative Immunology, Microbiology and Infectious Diseases, 90, p.101907.
Ashokcoomar, S., Reedoy, K.S., Beukes, D., van Reenen, M., Pillay, B. and Pillay, M., 2022.

3.A Comparison of the Genotoxic Effects of Gold Nanoparticles Functionalized with Seven Different Ligands in Cultured Human Hepatocellular Carcinoma Cells. Nanomaterials, 12(7), p.1126.
Mulder, D., Taute, C.J.F., van Wyk, M. and Pretorius, P.J., 2022.

4.The Effect of Capping Agents on Gold Nanostar Stability, Functionalization, and Colorimetric Biosensing Capability. Nanomaterials, 12(14), p.2470.
Munyayi, T.A., Vorster, B.C. and Mulder, D.W., 2022.

5.Association of the metabolic syndrome with PAI 1act and clot lysis time over a 10-year follow up in an African population. Nutrition, Metabolism and Cardiovascular Diseases, 33(3), pp.592-601.
Swanepoel, A.C., van Reenen, M., de Lange-Loots, Z. and Pieters, M., 2023.

6.Veranderinge in die urienmetaboloom van tuberkulosepasiënte tydens suksesvolle en onsuksesvolle behandeling. Suid-Afrikaans Tydskrif vir Natuurwetenskap en Tegnologie/South African Journal of Science and Technology, 41(1), pp.130-130.
Opperman, M., Loots, D.T. and du Preez, I., 2022.

1.M. tuberculosis curli pili (MTP) is associated with alterations in carbon, fatty acid and amino acid metabolism in a THP-1 macrophage infection model. Microbial Pathogenesis, 154, p.104806.
Ashokcoomar, S., Beukes, D., van Reenen, M., Pillay, B. and Pillay, M., 2021.

2.An Overview of Benefits and Challenges of Rare Disease Biobanking in Africa, Focusing on South Africa. Biopreservation and Biobanking, 19(2), pp.143-150.
Conradie, E.H., Malherbe, H., Hendriksz, C.J., Dercksen, M. and Vorster, B.C., 2021.

3.Chronological Metabolic Response to Intensive Phase TB Therapy in Patients with Cured and Failed Treatment Outcomes. ACS Infectious Diseases.
Opperman, M., Loots, D.T., van Reenen, M., Ronacher, K., Walzl, G. and du Preez, I., 2021.

4.Randomized control trial of oral arginine therapy for children with sickle cell anemia hospitalized for pain in Nigeria. American Journal of Hematology, 96(1), pp.89-97.
Onalo, R., Cooper, P., Cilliers, A., Vorster, B.C., Uche, N.A., Oluseyi, O.O., Onalo, V.D., Zubairu, Y., Ayodele‐Kehinde, A.U., Damilare, O.M. and Figueroa, J., 2021.

5.Novel Mutation in the IDS Gene in Hunter Syndrome Associated with Severe Cardiac Lesions. Clinical Chemistry, 67(3), pp.564-566.
Satekge, T.M., Honey, E.M., Pitso, B., Dercksen, M. and Pillay, T.S., 2021.

6.The effect of combined oral contraceptives containing drospirenone and ethinylestradiol on serum levels of amino acids and acylcarnitines. Metabolomics, 17(9), pp.1-11.
Swanepoel, A., Bester, J., Kruger, Y., Davoren, E. and du Preez, I., 2021.

7.Metabolic and Lipoprotein Profiling of Pancreatic Ductal Adenocarcinoma Patients of African Ancestry.
Elebo, N., Omoshoro-Jones, J., Fonteh-Fru, P., Devar, J., van Zyl, C.D.W., Vorster, B.C., Smith, M., Cacciatore, S., Zerbini, L.F., Candy, G. and Nweke, E.E., 2021.

8.Undiagnosed PKU Can Exist Everywhere: Results From an International Survey. The Journal of pediatrics, pp.S0022-3476.
van Wegberg, A.M.J., Trefz, F., Gizewska, M., Ahmed, S., Chabraoui, L., Zaki, M.S., Maillot, van Spronsen, F.J., Dercksen, M, et. al. 2021.

1.Tween 80 induces a carbon flux rerouting in Mycobacterium tuberculosis. Journal of microbiological methods, 170, p.105795.
Pietersen, R.D., Du Preez, I., Loots, D.T, van Reenen, M., Beukes, D., Leisching, G. and Baker, B., 2020.

2.Metabolomics describes previously unknown toxicity mechanisms of isoniazid and rifampicin. Toxicology letters, 322, pp.104-110.
Combrink, M., Loots, D.T, and du Preez, I., 2020.

3.A call for global action for rare diseases in Africa. Nature genetics, 52(1), pp.21-26.
Baynam, G.S., Groft, S., van der Westhuizen, F.H., Gassman, S.D., du Plessis, K., Coles, E.P., Selebatso, E., Selebatso, M., Gaobinelwe, B., Selebatso, T., Joel, D., Llera, V.A., Vorster, B.C.., et al. 2020.

4.Serum metabolome changes in relation to prothrombotic state induced by combined oral contraceptives with drospirenone and ethinylestradiol. OMICS: A Journal of Integrative Biology, 24(7), pp.404-414.
Swanepoel, A.C., Bester, J., Emmerson, O., Soma, P., Beukes, D., Van Reenen, M., Loots, D.T. and Du Preez, I., 2020.

5.The echo of pulmonary tuberculosis: mechanisms of clinical symptoms and other disease-induced systemic complications. Clinical Microbiology Reviews, 33(4), pp.e00036-20.Serum metabolome changes in relation to prothrombotic state induced by combined oral contraceptives with drospirenone and ethinylestradiol. OMICS: A Journal of Integrative Biology, 24(7), pp.404-414.
Luies, L. and Du Preez, I., 2020.

6.Pediatric biobanking: Kids are not just little adults. Biopreservation and biobanking, 18(4), pp.258-265.
Catchpoole, D.R., Carpentieri, D., Vercauteren, S., Wadhwa, L., Schleif, W., Zhou, L., Zhou, J., Labib, R.M., Smits, E. and Conradie, E.H., 2020.

7.Mycobacterium tuberculosis curli pili (MTP) deficiency is associated with alterations in cell wall biogenesis, fatty acid metabolism and amino acid synthesis. Metabolomics, 16(9), pp.1-15.
Ashokcoomar, S., Reedoy, K.S., Senzani, S., Loots, D.T., Beukes, D., Van Reenen, M., Pillay, B. and Pillay, M., 2020.

8.Mycobacterium tuberculosis curli pili (MTP) is associated with significant host metabolic pathways in an A549 epithelial cell infection model and contributes to the pathogenicity of Mycobacterium tuberculosis. Metabolomics, 16(11), pp.1-14.
Reedoy, K.S., Loots, D.T., Beukes, D., Van Reenen, M., Pillay, B. and Pillay, M., 2020.

9.Metallothionein 1 overexpression does not protect against mitochondrial disease pathology in Ndufs4 knockout mice. Molecular Neurobiology, 58(1), pp.243-262.
Miller, H.C., Louw, R., Mereis, M., Venter, G., Boshoff, J.D., Mienie, L., Van Reenen, M., Venter, M., Lindeque, J.Z., Domínguez-Martínez, A. and Quintana, A., 2021.

10.Metabolic characterization of tuberculous meningitis in a South African paediatric population using 1H NMR metabolomics. Journal of Infection, 81(5), pp.743-752.
Van Zyl, C.D.W., Solomons, R., Van Reenen, M. and Mason, S., 2020.

11.The unaided recovery of marathon-induced serum metabolome alterations. Scientific Reports, 10(1), pp.1-11.
Stander, Z., Luies, L., Mienie, L.J., Van Reenen, M., Howatson, G., Keane, K.M., Clifford, T. and Stevenson, E.J., 2020.

12.Disorders of flavin adenine dinucleotide metabolism: MADD and related deficiencies. The International Journal of Biochemistry & Cell Biology, p.105899.
Mereis, M., Wanders, R.J., Schoonen, M., Dercksen, M., Smuts, I. and van der Westhuizen, F.H., 2020.

1.Time-dependent changes in urinary metabolome before and after intensive phase tuberculosis therapy: a pharmacometabolomics study. Omics: a journal of integrative biology, 23(11), pp.560-572.
Combrink, M., Du Preez, I., Ronacher, K., Walzl, G. and Loots, D.T., 2019.

2.The application of metabolomics toward pulmonary tuberculosis research. Tuberculosis, 115, pp.126-139.
Du Preez, I. Luies, L., Loots, D.T. 2019.

3.Fatty acid metabolome extraction from mycobacterial cells for GC-MS metabolomics analysis. In Microbial Metabolomics (pp. 111-120). Humana Press, New York, NY.
Du Preez, I. Beukes, D., Loots, D. T. 2019.

4.Total metabolome extraction from mycobacterial cells for GC-MS metabolomics analysis. In Microbial Metabolomics (pp. 121-131). Humana Press, New York, NY.
Beukes, D. Du Preez, I., Loots, D.T 2019.

5.Gold nanostar colorimetric detection of fructosyl valine as a potential future point of care biosensor candidate for glycated haemoglobin detection. Biosensors, 9(3), p.100.
Mulder, D.W., Phiri, M.M. and Vorster, B.C., 2019.

6.Tailor-made gold nanostar colorimetric detection determined by morphology change and used as an indirect approach by using hydrogen peroxide to determine glucose concentration. Sensing and Bio-Sensing Research, 25, p.100296.
Mulder, D., Phiri, M.M. and Vorster, B.C., 2019.

7.Plasmonic detection of glucose in serum based on biocatalytic shape-altering of gold nanostars. Biosensors, 9(3), p.83.
Phiri, M.M., Mulder, D.W. and Vorster, B.C., 2019.

8.Modified HEPES one-pot synthetic strategy for gold nanostars. Royal Society open science, 6(6), p.190160.
Mulder, D.W., Phiri, M.M., Jordaan, A. and Vorster, B.C., 2019.

9.Biotransformation profiles from a cohort of chronic fatigue women in response to a hepatic detoxification challenge. Plos one, 14(5), p.e0216298.
Erasmus, E., Steffens, F.E., Van Reenen, M., Vorster, B.C. and Reinecke, C.J., 2019.

10.Facile immobilization of glucose oxidase onto gold nanostars with enhanced binding affinity and optimal function. Royal Society open science, 6(5), p.190205.
Moses Phiri, M., Wingrove Mulder, D., Mason, S. and Christiaan Vorster, B., 2019.

11.Seedless gold nanostars with seed-like advantages for biosensing applications. Royal Society open science, 6(2), p.181971.
Phiri, M.M., Mulder, D.W. and Vorster, B.C., 2019.

12.A laboratory approach for characterizing chronic fatigue: what does metabolomics tell us?. Metabolomics, 15(12), pp.1-11.
Erasmus, E., Mason, S., Van Reenen, M., Steffens, F.E., Vorster, B.C. and Reinecke, C.J., 2019.

13.The GC–MS metabolomics signature in patients with fibromyalgia syndrome directs to dysbiosis as an aspect contributing factor of FMS pathophysiology. Metabolomics, 15(4), pp.1-13.
Malatji, B.G., Mason, S., Mienie, L.J., Wevers, R.A., Meyer, H., Van Reenen, M. and Reinecke, C.J., 2019.